GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs10935120 | 1 | rs1880377 | chr3:134270468 | ANAPC13 | chr3:134196547-134204865:- | -0.5 | -7.97 | 1.89E-14 | Height |
| BLCA | cis | rs10935120 | 1 | rs1880377 | chr3:134270468 | CEP63 | chr3:134204575-134293852:+ | -0.24 | -4.09 | 5.33E-5 | Height |
| BLCA | cis | rs6951245 | 1 | rs1881123 | chr7:1084706 | ZFAND2A | chr7:1192544-1199855:- | -0.38 | -4.53 | 7.81E-6 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BLCA | cis | rs9309473 | 1 | rs1881245 | chr2:73649928 | ALMS1P | chr2:73872046-73912692:+ | 0.37 | 5.48 | 7.92E-8 | Metabolite levels |
| BLCA | cis | rs1499614 | 1 | rs1882655 | chr7:66147057 | CCT6P1 | chr7:65216092-65228661:+ | -0.38 | -4.99 | 9.26E-7 | Gout |
| BLCA | cis | rs1884537 | 1 | rs1884537 | chr14:101251989 | DLK1 | chr14:101193253-101201474:+ | -0.18 | -3.95 | 9.46E-5 | Optic nerve measurement (disc area) |
| BLCA | cis | rs7714584 | 1 | rs1896707 | chr5:150245129 | LOC134466 | chr5:150310000-150326146:- | 0.43 | 5.76 | 1.69E-8 | Crohn's disease |
| BLCA | cis | rs7714584 | 1 | rs1896708 | chr5:150245076 | LOC134466 | chr5:150310000-150326146:- | 0.44 | 5.84 | 1.12E-8 | Crohn's disease |
| BLCA | cis | rs7714584 | 1 | rs1896709 | chr5:150245032 | LOC134466 | chr5:150310000-150326146:- | 0.43 | 5.77 | 1.66E-8 | Crohn's disease |
| BLCA | cis | rs732528 | 1 | rs1899669 | chr18:48371698 | MRO | chr18:48321491-48351754:- | -0.22 | -4.09 | 5.36E-5 | Entorhinal cortical thickness |
| BLCA | cis | rs9475752 | 1 | rs1903330 | chr6:56776985 | BEND6 | chr6:56819773-56892138:+ | 0.3 | 4.17 | 3.82E-5 | Menarche (age at onset) |
| BLCA | cis | rs10461617 | 1 | rs190414 | chr5:56116772 | C5orf35 | chr5:56205103-56213010:+ | 0.74 | 11.19 | 2.38E-25 | Type 2 diabetes |
| BLCA | cis | rs12220238 | 1 | rs1908331 | chr10:75885817 | ADK | chr10:75910965-76469059:+ | 0.31 | 4.77 | 2.57E-6 | Soluble interleukin-2 receptor subunit alpha |
| BLCA | cis | rs950169 | 1 | rs1911155 | chr15:84787635 | LOC388152 | chr15:84867600-84898920:- | -0.28 | -4.87 | 1.63E-6 | Schizophrenia |
| BLCA | cis | rs1577917 | 1 | rs1911552 | chr6:86638024 | SNHG5 | chr6:86386726-86388451:- | -0.55 | -10.02 | 3.91E-21 | Response to antipsychotic treatment |